Nanobrid® Technology Platform

Nanobrid® is proprietary next generation lipidic and polymeric nanoparticle system

Stable, prolong drug release

Lower particles size & narrow size distribution

Possible surface modifications

Lower drug entrapment & scale-up issues

Higher cost of manufacturing

Stability issue, possible burst release

Limited surface modification possibility

No toxicity issues

Higher drug entrapment

Lower cost of manufacturing

Nanobrid® Platform

  • Nanobrid® platform uses solid-lipid, liquid-lipid, and amphiphilic polymer that comes together to form monolithic type hybrid nanoparticles (<200 nm size)
  • Active ingredient (lipid soluble) gets encapsulated in the hydrophobic core
  • Hydrophilic (water soluble) portion of polymer arranges outside core and interacts with aqueous phase and is responsible for offering stability
  • Surface modification of polymer offers possibility for targeted delivery (for example to liver, brain, and cancer cells)
  • Nanobrid® platform offers flexibility of selecting variety of polymers, lipids, and surfactants to optimize formulation characteristics based on target candidate and desired target product profile

Nanobrid® advantage

Nanobrid® platform presents broad applicability in drug delivery by enhancing formulation to improve efficacy, safety and patient convenience. Below are potential use cases

Potential use case

Nanobrid® solution

Poor bioavailability: Difficulty in delivering active ingredient to skin or nails limiting efficacy

  • Nanobrid formulation reaches to deeper level of disease affected skin or nails.
  • Slow and sustained release of active ingredient improves therapeutic outcome.

Poor safety profile: product cannot be used for more than two weeks when used topically due to increased risk of systemic side-effects.

  • Nanobrid formulation reduce risk of absorption of active ingredient into blood circulation and therefore can be used for a longer duration.
  • Nanobrid formulation require reduced dose to produce similar or superior therapeutic effect due to improved cellular uptake
Patient inconvenience: Patients expressed discomfort applying oily greasy creams and discontinuing prescribed treatment.
  • Nanobrid transparent gel formulation gets absorbed in skin quickly and is suitable for the application in the visible part of body (e.g. face and hands) without risk of getting noticed.